|
KMID : 0613820180280040465
|
|
Journal of Life Science
2018 Volume.28 No. 4 p.465 ~ p.471
|
|
|
Beneficial Effects of Nano-sized Bee Pollen on Testosterone-induced Benign Prostatic Hyperplasia in Rodents
|
|
Bak Ji-A
Pyeon Hae-In
So Soo-Jeong
Lee Seung-Hyun
Lee Seung-Min
Suh Hwa-Jin
Kang Jae-Seon
Choi Yun-Sik
Chung Il-Kyung
|
|
|
Abstract
|
|
|
|
Bee pollen is one of many types of alternative remedies, and it has been used for a long time throughout the world. It has numerous health effects, including antifungal, antibacterial, and antioxidant properties, immune modulation, enhanced cell proliferation, and even anti-carcinogenic effects. This study was designed to elucidate the effects of bee pollen on benign prostatic hyperplasia in rodents. For this experiment, we used nano-sized bee pollen produced through wet-grinding technology, thereby the extraction efficiency of the active ingredients in the bee pollen was significantly enhanced. First, We found that nano-sized bee pollen significantly reduced the size of prostates enlarged by chronic testosterone administration. In addition, nano-sized bee pollen significantly reduced the plasma concentration of the prostate-specific antigen (PSA). Interestingly, nano-sized bee pollen did not reduce the testosterone-induced increase in the plasma concentration of prostaglandin E2 (PGE2). The beneficial effects of nano-sized bee pollen in reducing both the size of the prostate and the plasma concentration of PSA was comparable to that of dutasteride. Finally, nano-sized bee pollen did not cause damage in LNCaP cells which are androgen-sensitive human prostate adenocarcinoma cells. Together, these data indicate that nano-sized bee pollen may be able to be used as a good alternative remedy for the treatment of benign prostatic hyperplasia.
|
|
|
KEYWORD
|
|
|
Bee pollen, benign prostatic hyperplasia, dutasteride, prostate specific antigen, prostaglandin E2
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|